Original Article

J Korean Hip Soc 2008; 20(4): 320-325

Published online December 1, 2008

© The Korean Hip Society

무혈성 괴사에 이환된 대퇴골두 연골세포의 세포외 기질 mRNA 발현

정환용∙이우석∙김상범∙배인탁∙박원기

건양대학교 의과대학 정형외과학교실

Received: August 13, 2008; Revised: September 8, 2008; Accepted: November 24, 2008

The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis

Whan-Young Chung, M.D., Woo-Suk Lee, M.D., Sang-Bum Kim, M.D., In-Tak Bae, M.D., Won-Ki Park, M.D.

Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea

Correspondence to : 이우석
대전광역시 서구 가수원동 685 건양대학교 의과대학 정형외과학교실
TEL: 82-42-600-6903
FAX: 82-42-545-2373
E-mail: wsleeos@kyuh.co.kr

* 본 논문은 2005년도 건양대학교 명곡 학술연구비에 지원을 받았음.

Received: August 13, 2008; Revised: September 8, 2008; Accepted: November 24, 2008

Abstract

Purpose: The aim of this study was to evaluate the expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).
Materials and Methods: We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF.
Results: The chondrocytes of the AVN group showed decreased expressions of type Ⅱ collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).
Conclusion: The cartilage matrix’s formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.

Keywords Avacular necrosis, Chondrocytes, Type II collagen, Aggrecan, VEGF-A, PEDF

Article

Original Article

J Korean Hip Soc 2008; 20(4): 320-325

Published online December 1, 2008 https://doi.org/10.5371/jkhs.2008.20.4.320

Copyright © The Korean Hip Society.

무혈성 괴사에 이환된 대퇴골두 연골세포의 세포외 기질 mRNA 발현

정환용∙이우석∙김상범∙배인탁∙박원기

건양대학교 의과대학 정형외과학교실

Received: August 13, 2008; Revised: September 8, 2008; Accepted: November 24, 2008

The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis

Whan-Young Chung, M.D., Woo-Suk Lee, M.D., Sang-Bum Kim, M.D., In-Tak Bae, M.D., Won-Ki Park, M.D.

Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea

Correspondence to:이우석
대전광역시 서구 가수원동 685 건양대학교 의과대학 정형외과학교실
TEL: 82-42-600-6903
FAX: 82-42-545-2373
E-mail: wsleeos@kyuh.co.kr

* 본 논문은 2005년도 건양대학교 명곡 학술연구비에 지원을 받았음.

Received: August 13, 2008; Revised: September 8, 2008; Accepted: November 24, 2008

Abstract

Purpose: The aim of this study was to evaluate the expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).
Materials and Methods: We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF.
Results: The chondrocytes of the AVN group showed decreased expressions of type Ⅱ collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).
Conclusion: The cartilage matrix’s formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.

Keywords: Avacular necrosis, Chondrocytes, Type II collagen, Aggrecan, VEGF-A, PEDF

Hip & Pelvis